Polioksidony has immunomodulatory effect, increases the body’s resistance against local and generalized infections. The basis of the mechanism of immunomodulatory effects Polyoxidonium a direct effect on the phagocytic cells and natural halotestin buy killer cells, and stimulation of antibody production.
Polioksidony restores immunity in secondary immunodeficiency, caused by various infections, injuries, burns, autoimmune diseases, malignancies, complications after surgery, the use of chemotherapeutic agents, cytotoxic drugs, steroid hormones.
Along with immunomodulatory effects, has expressed polioksidony detoxification and antioxidant activity, has the ability to rid the body of toxins, heavy metals, inhibits lipid peroxidation. These properties are determined by the structure and nature of the high-molecular Polyoxidonium. Turning Polyoxidonium in the complex therapy of cancer patients reduces intoxication on the background of chemotherapy and radiation therapy, in most cases, allows to treat without changing the standard treatment schemes in connection with the development of infectious complications and side effects (myelosuppression, vomiting, diarrhea, cystitis, colitis, and others) .
Application Polyoxidonium on the background of secondary immunodeficient states to improve the efficiency and reduce the duration of treatment, significantly reduce halotestin buy the use of antibiotics, bronchodilators, corticosteroids, lengthen remission.
The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, it does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
Polioksidony suppositories for rectal administration has a high bioavailability (not less than 70%), reaching a maximum concentration in the blood after 1 hour after administration. poluraspredeleniya period – approximately 0.5 hours, elimination half – 36.2 hours. In the body, it is hydrolyzed to oligomers, which are derived primarily by the kidneys. The cumulative effect is not.
In adults and children older than 6 years in the treatment of immune deficiency correction:
– Chronic recurrent infectious and inflammatory diseases, not amenable to standard therapy in the acute phase and in remission;
– acute viral, bacterial and fungal infections
– inflammatory diseases of the urogenital tract, including urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, vaginitis, cervicitis, tservikoza, bacterial vaginosis, including viral etiology;
– different forms of tuberculosis;
– allergic diseases, complicated by recurrent bacterial, fungal and viral infections (including hay fever, asthma, atopic dermatitis);
– rheumatoid arthritis, long-term treatment immunosuppressant; in complicated acute respiratory disease SARS, or course of the disease;
– to activate regenerative processes (fractures, burns, trophic ulcers);
– for the rehabilitation and often long-term (more than 4-5 times per year) ill persons;
– during and after chemotherapy and radiotherapy tumors;
– to reduce nephrotoxicity – and hepatotoxic drugs.
– For the prevention halotestin buy of recurrent herpes infection;
– for the prevention of seasonal exacerbation of chronic foci of infection; for the prevention of influenza and acute respiratory diseases in pre-epidemic period;
– for the correction of secondary immunodeficiency, resulting from aging or exposure to adverse factors.
Individual hypersensitivity. Pregnancy, lactation (no clinical experience).
Acute renal failure.
DOSAGE AND ADMINISTRATION:
Polioksidony suppositories 6 mg and 12 mg rectally and vaginally applied 1 time a day. The method and dosing schedule determined by the physician depending on the diagnosis, severity and the severity of the process. Polioksidony can be used rectally and vaginally daily, every other day or 2 times a week.
Polioksidony suppositories, 12 mg is used in adults rectally 1 suppository 1 time a day after cleansing the bowel,
gynecological diseases and vaginally inserted into the vagina in the supine position 1 suppository 1 time a day (at night).
Polioksidony suppositories 6 mg is applied:
in children older than 6 years rectally 1 suppository 1 time a day after cleansing the bowel; adult vaginally and rectally as a maintenance dose of 1 suppository 1 time a day (at night) is inserted into the vagina lying position.
The standard application circuit
1 suppository 6 mg or 12 mg 1 time a day every day for 3 days, then every other day course of 10-20 suppositories. If necessary, halotestin buy repeat the treatment after 3-4 months.