Has plazmozameshchath. antishock, complementary blood volume and antiplatelet effect. Due to halotestin for sale the high osmotic pressure greater than 2.5 times the plasma protein oncotic pressure, causing the active involvement of tissue fluid (20-25 ml per g of polymer I) and keeps it in the bloodstream long enough period, and therefore the volume of circulating blood by intravenous administration of the drug quickly restored. It eliminates disorders of systemic hemodynamics, increases blood pressure. Improves the stability of the suspension of blood, has a pronounced anti-adhesive and antiplatelet effects on platelets, promotes the elimination of peripheral stasis and aggregation of red blood cells, improves microcirculation, may reduce the risk of disseminated intravascular coagulation of blood. Non-toxic, non-pyrogenic.
Excreted primarily by the kidneys; within the first 24 hours it is eliminated about 50%, and after 3 days but it should be determined in the blood. A small part of dextran accumulates in the reticuloendothelial system, which is gradually metabolized to dextrose. From the bloodstream completely removed at 5-7 hours.
Treatment of hemorrhagic, traumatic, burns, toxic and cardiogenic shock; preparing patients for surgery for the purpose of detoxification with burns and other conditions involving halotestin for sale intoxication.
: Hypersensitivity to the drug dextran, cardiovascular failure, continuing internal bleeding (liver, lungs, kidneys), traumatic brain injury, intracranial hypertension, hemorrhagic stroke, anuria, severe chronic renal failure, thrombocytopenia, clinical situations in which the undesirable introduction large volumes of liquids (including hypertension, hypervolemia on background hematocrit below 0.3). Precautions: severe dehydration.
Pregnancy and lactation
In pregnancy, the drug is prescribed only for health reasons. Data about the contraindications of the drug during lactation is not.
Dosage and administration: Intravenous bolus or infusion, acute blood loss intra.
The volume and rate of administration is determined by the condition of the patient, the blood pressure value, heart rate, hematocrit.
Transfusion is performed in the usual way in compliance with the rules of the production of transfusion: transfusion is carried out before the biological sample (after the introduction of 5-10 cap made 3 minutes break, then poured another 10-15 cap and after the break of the same reaction in the absence of symptoms (increased heart rate, halotestin for saledecreased blood pressure , redness of the skin, shortness of breath) continue pouring When razvivshemsya shock or acute hemorrhage -.. intravenously, 0.4-2 liters (5-25 mL / kg) After the blood pressure increase up to 80-90 mm Hg usually pass to a drip at a rate of 3-3.5 ml / min (60-80 drops / min). Chance of intra-arterial routes of administration (at the same doses). Infusion of the drug must be under the permanent control of the main indicators of systemic hemodynamics. with a significant increase in central venous pressure, reduce the dose and rate of administration or completely stopped.
When blood loss more than 500-750 ml and the patient expressed anemizatsii combine administration of the drug to the blood transfusion of packed red cells or red blood cell suspension needed for the elimination of tissue hypoxia, as well as fresh-frozen plasma, containing factors of the hemostatic system.
For the prevention of blood loss operating, as well as to achieve artificial hemodilution, prevent thrombus formation and reduce the tendency to the development or progression of disseminated intravascular clotting drug is administered in doses of 10.5 ml / kg (children – 10-15 ml / kg) 30 60 minutes before surgical intervention (in the case of a significant reduction in blood pressure pass to bolus at lowering blood pressure below 60 mm Hg -vnutriarterialnoe introduction). The volume of infusion during surgical exposure is determined by the size of the operating loss of blood (hematocrit should not fall below 0.3).Postoperatively, jet-drip is an effective way of preventing shock.
When burn shock: the first 24 hours in 2.3 liters administered in the following 24 hours – 1.5 liter. Children in the first 24 hours -40-50 ml / kg, the next day – 30 ml / kg. At extensive and deep burns combined with the introduction of plasma, albumin, gamma globulin; with burns over 30-40% of the body surface – with a blood transfusion. recommended infusion of the drug to prevent possible dehydration fabrics combined with the introduction of crystalloid solutions in share ratio of 1: 2.
Allergic (redness and itching of the skin, swelling angionsvrotichssky) or anaphylactic reactions (rare – less than 0.001%).
It is necessary to immediately stop the introduction of the drug and, if necessary, without removing the needle from the vein, to initiate measures for the elimination of transfusion reactions (antihistamines, cardiovascular agents, glucocorticosteroids, a respiratory analeptic).
With the rapid introduction of dextrans in large amounts can trigger the development of acute left ventricular halotestin for sale failure and pulmonary edema.
In case of complaints of chest tightness, shortness of breath, back pain, as well as in the event of fever, cyanosis, poor circulation and respiration transfusion should be stopped, intravenously introduce 10 ml of 10% calcium chloride solution, 20 ml of 40% dextrose, antihistamines, corticosteroids and have the appropriate symptomatic therapy.